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Feature
Our primary focus is on the biopharmaceuticals derived from the botulinum
neurotoxin as therapeutics. As the first project, we developed a botulinum
toxin type A product as injectables. We are also working on the development
B & E products.
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The specification of our product is equivalent and/or superior to those
of other competitors. Especially, our extreme focus is on the highest
quality control/assurance and the minimal variation of the toxin quantity
in a vial.
Product Specification
- Dosage Form: Inject able
- Appearance: A White Lyophilized Cake
Composition in 1 Vial
- Active Pharmaceutical Ingredient: 100 units*
- Human Serum Albumin: 0.5 mg
- Sodium Chloride: 0.9 mg
* ICR Mouse LD50
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| What is Clostridium Botulinum? |
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- Strict Anaerobe
- Endospore former
- Classified A, B, C1, C2, D, E, F, G
- One of the most toxic microbes
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Pharmaceutical Mechanism
Therapeutic Efficacy (Neuronox vs. Botox)
- Application: Hemifacial spasm
- Statistically equivalent between both products
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Cosmetic
Efficacy: EMG data
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Left
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Right
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| Source: CJ, Connexion, and Medy-Tox |
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Treatment with Medy-Tox's Botulinum Toxin
Product
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Before
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After
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Source: CJ, Connexion and Medy-Tox
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Indications for Botulinum Pharmaceuticals
* Most of the following diseases have almost no appropriate therapies
currently available. |
1) Neurology
- Blepharospasm
- Cerebral Palsy
- Cervical dystonia
- Hemifacial spasm
- Hemimasticatory spasm
- Maseteric hypertrophy
- Meige's syndrome
- Muculi maseter spasm
- Myoclonus
- Myofascial pain syndrome
- Myokymia
- Paradoxic Jaw muscle activity
- Plaltal myoclonus
- Rigidity of progressive supranuclear palsy
- Spasticity after stroke
- Tremor
- Trismus in cephalic tetanus
- Upper extremities dystonia
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3) Gastroenterology
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4) Gynaecology
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5) Urology
- Bladder sphincter spasm
- Detrusor sphincter dyssynergia
- Prostate hyperplasia
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6) Exocrine gland hyperactivity
- Crocodile tears syndrome
- Frey's syndrome
- Hyperhidrosis
- Relative hypersalivation
- Rhinorrhea
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2) Ophthalmology
- Esotropia
- Exotropia
- Mixed strabismus
- Multiple sclerosis
- Myositic strabismus
- Myopathic strabismus
- Nystagmus
- Oscillopsia
- Paralytic strabismus
- Protective ptosis
- Strabismus after aphakia
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7) Cosmetic uses
- Hyperactive facial lines
- Eye brow elevation
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8) Orthopaedia surgery
- Postoperative immobilization
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Clinical Trials: Hemifacial Spasm
All the tests were carried out under the regulations of the KFDA(Korean
Food & Drug Administion) equivalent to the ICH/WHO guidelines.
The title of the Phase III clinical trial is as follows.
"Double blinded, randomized, active drug comparative, parallel designed,
multi-center, phase III clinical study for the safety and the efficacy
of Meditoxin(tentative name) inj. in hemifacial spasm patients"
4 major University & General hospitals participated in the clinical trials.
The results were excellent and concluded very successful by the Institutional
Review Board of each hospital.
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